circRNA basic information
circBase ID: -
Name: hsa_circ_NOX4
Synonym: circNOX4
Host Gene: NOX4
Genomic location(hg19): chr11:89069012-89106660:-
Genomic location(hg38): chr11:89335844-89373492:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0022470
MONDO name: aortic dissection lentiginosis
Disease details: Stanford type A aortic dissection / TAAD
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ascending aortic tissues; peripheral blood serum / plasma serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with inflammatory cell infiltration and stromal loss in TAAD; may participate in loss of VSMCs; circulating diagnostic biomarker for TAAD.
Molecular mechanism: Predicted ceRNA regulation via circRNA-miRNA-mRNA network; specific miRNAs not reported for circNOX4 (unannotated in circBank).
Biological pathway or process:

inflammation (promotes); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High expression in peripheral plasma serum with diagnostic capability to distinguish TAAD from healthy controls (AUC = 0.9 for circNOX4).
Description:

circNOX4 is up-regulated in TAAD (aortic tissue and serum) and has diagnostic value. It is associated with inflammatory infiltration and stromal/VSMC loss in TAAD, with mechanisms explored mainly through bioinformatic ceRNA/pathology correlation analyses rather than a specified miRNA/mRNA pair for this circRNA.
Confidence score:

0.5047
Other information
Title:

Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection.

Journal: Frontiers in cardiovascular medicine
Published: 2022
PubMed ID: 36712253
Study type:

combined biological and clinical study
Data availability: GSE153434
Code availability: code available by request to the corresponding authors