| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-26b |
| Biological function: |
Associated with TAAD pathology and serves as a circulating diagnostic biomarker; implicated in inflammation promotion, ECM degradation and stromal component loss via miRNA interactions. |
| Molecular mechanism: |
ceRNA network (circRNA-miRNA-mRNA) prediction; circPTGR1-miR-26b-HMGA2 regulatory chain. |
| Biological pathway or process: |
inflammation (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression in peripheral plasma serum with diagnostic capability to distinguish TAAD from healthy controls (AUC = 0.987 for circPTGR1). |
| Description: |
circPTGR1 is up-regulated in TAAD (aortic tissue and serum) and shows strong diagnostic performance. Mechanistically, it is implicated in a predicted ceRNA axis circPTGR1-miR-26b-HMGA2 and is associated with inflammatory responses and ECM/stromal loss in TAAD. |
| Confidence score: |
0.5047 |