| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-766-5p, hsa-miR-765, hsa-miR-30c-1-3p, hsa-miR-4716-3p |
| Biological function: |
pro-apoptosis; promotes inflammatory cytokine secretion; inhibits proliferation (silencing reverses these phenotypes) |
| Molecular mechanism: |
ceRNA mechanism via regulating multiple miRNAs |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); inflammation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; TUNEL; CCK8; ELISA; Microarray |
| Clinical significance: |
identified as novel biomarkers for OA |
| Description: |
hsa_circ_0102564 is up-regulated in osteoarthritic cartilage and is a hub circRNA in the predicted circRNA-miRNA-mRNA network, regulating miRNAs including hsa-miR-766-5p and hsa-miR-30c-1-3p. Functional knockdown in IL-1beta-treated C28/I2 chondrocytes reduces apoptosis and inflammatory cytokine secretion and restores proliferation, supporting a pro-apoptotic/pro-inflammatory role in OA. |
| Confidence score: |
0.6777 |