| Expression pattern: |
UP |
| Associated gene: |
SMARCA5 |
| Associated microRNA: |
- |
| Biological function: |
Promotes cell proliferation, migration and invasion, and represses apoptosis in bladder cancer cells. |
| Molecular mechanism: |
circ-SMARCA5 positively regulates SMARCA5 expression; detailed downstream mechanism was not investigated. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
Potential therapeutic target in bladder cancer. |
| Description: |
circ-SMARCA5 (hsa_circ_0001445) is up-regulated in bladder cancer tissues and several bladder cancer cell lines. Gain- and loss-of-function experiments in UM-UC-3 cells show it promotes proliferation, migration and invasion while inhibiting apoptosis, and it positively affects SMARCA5 expression. |
| Confidence score: |
0.6825 |