| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-140-3p, hsa-miR-766-5p, hsa-miR-1260b, hsa-miR-516b-5p, hsa-miR-4443, hsa-miR-4739, hsa-miR-3202 |
| Biological function: |
pro-apoptosis; promotes inflammatory cytokine secretion; inhibits proliferation (silencing reverses these phenotypes) |
| Molecular mechanism: |
ceRNA mechanism via regulating multiple miRNAs |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); inflammation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; TUNEL; CCK8; ELISA; Microarray |
| Clinical significance: |
identified as novel biomarkers for OA |
| Description: |
hsa_circ_0027914 is up-regulated in osteoarthritic cartilage and functions as a hub circRNA in a predicted circRNA-miRNA-mRNA network. siRNA-mediated silencing reduces IL-1beta-induced chondrocyte apoptosis, decreases IL-6/TNF-alpha secretion, and restores proliferation, consistent with a pro-apoptotic and pro-inflammatory role in OA. |
| Confidence score: |
0.6777 |