circRNA basic information
circBase ID: hsa_circ_0110529
Name: hsa_circ_PTPN22
Synonym: circ-PTPN22
Host Gene: PTPN22
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003210
MONDO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma / ICC
Disease DO ID:
 4928
Disease MeSH ID:
 -
Disease NCIt ID:
 C35417
Disease ICD11 ID:
 1253728223; 387909164
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ICC tumor tissues; adjacent normal tissues; plasma exosomes
Cell lines:

293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Marks a subgroup of immunogenic Asian ICC characterized by T cell exhaustion and neutrophil extracellular traps; potential liquid biopsy biomarker.
Molecular mechanism: Not specified; reported as elevated exosomal/tissue biomarker derived from post-transcriptional backsplicing of PTPN22.
Biological pathway or process:

immune regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Elevated in ICC tumor tissues and plasma exosomes of an immunogenic Asian ICC subgroup; potential liquid biopsy biomarker.
Description:

circ-PTPN22 is up-regulated in an immunogenic Asian ICC subgroup (subgroup 2) and is elevated in both tumor tissues and plasma exosomes, marking T cell exhaustion and neutrophil extracellular traps. The study validates its circular nature and upregulation by qRT-PCR, Sanger sequencing of the back-splice junction, and RNase R resistance, supporting its potential as a liquid-biopsy biomarker.
Confidence score:

0.6193
Other information
Title:

Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma.

Journal: Molecular therapy. Nucleic acids
Published: 2023
PubMed ID: 36700045
Study type:

combined biological and clinical study
Data availability: GSE188330; PRJNA777408; GSE181523; GSE148561; GSE138709
Code availability: https://github.com/Selecton98/CircRNA_4DGlab2; https://github.com/Selecton98/CircRNA_ICC