| Expression pattern: |
DN |
| Associated gene: |
QKI-5 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits HCC proliferation, promotes apoptosis, and increases sensitivity of HCC cells to sorafenib. |
| Molecular mechanism: |
circZKSCAN1 encodes the peptide circZKSaa; the miRNA sponge function is weak in HCC. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); chemoresistance (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Transfection; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circZKSCAN1 is down-regulated in HCC tissues/cell lines and suppresses HCC cell growth while increasing sorafenib sensitivity. The study indicates its main functional output in HCC is likely via encoding the peptide circZKSaa rather than acting as a miRNA sponge. |
| Confidence score: |
0.6578 |