circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: circSMARCA5 / circular RNA SMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC tissue; matched nontumor tissue / adjacent normal tissues
Cell lines:

CNE1; CNE2; HONE1; HENE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: miR-582-3p
Biological function: promotes proliferation, migration and invasion; inhibits apoptosis; promotes EMT in nasopharyngeal carcinoma cells
Molecular mechanism: ceRNA mechanism: circSMARCA5 sponges miR-582-3p to relieve repression of PTEN
Biological pathway or process:

EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

circSMARCA5 might be a biomarker for NPC diagnosis and treatment
Description:

circSMARCA5 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-582-3p to increase PTEN, forming a circSMARCA5/miR-582-3p/PTEN axis.
Confidence score:

0.6536
Other information
Title:

Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis.

Journal: Evidence-based complementary and alternative medicine : eCAM
Published: 2023
PubMed ID: 36686977
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon request.
Code availability: -