circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: hsa_circRNA_103831
Host Gene: HMGCS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TP53
Associated microRNA: hsa-let-7c-5p
Biological function: Potential diagnostic biomarker for CRC (high diagnostic efficiency by ROC); suggested involvement in CRC pathogenesis.
Molecular mechanism: Predicted ceRNA network (cirReNET) and proposed core axis hsa_circRNA_103831-hsa-let-7c-5p-TP53 (bioinformatics prediction).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic marker for CRC (ROC AUC = 0.7502).
Description:

hsa_circRNA_103831 (host gene HMGCS1) is up-regulated in CRC tissues and has diagnostic value (AUC 0.7502). A predicted ceRNA axis hsa_circRNA_103831-hsa-let-7c-5p-TP53 is proposed based on bioinformatics and TCGA-based hub gene screening, without direct mechanistic validation.
Confidence score:

0.5963
Other information
Title:

Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.

Journal: PeerJ
Published: 2022
PubMed ID: 35611168
Study type:

combined biological and clinical study
Data availability: GSE197991; Supplemental File
Code availability: -