| Expression pattern: |
DN |
| Associated gene: |
MYC, NOTCH1, FBXW7 |
| Associated microRNA: |
- |
| Biological function: |
Tumor suppressor role in T-ALL; circFBXW7 depletion increases leukemic cell viability and proliferation and is linked with MYC and NOTCH1 hyperactivation; increases Dexamethasone sensitivity. |
| Molecular mechanism: |
circFBXW7 depletion activates MYC signaling and NOTCH signaling (increased MYC protein and NOTCH1 cleaved intracellular domain; upregulation of MYC target genes and NOTCH signaling genes). |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); Notch (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Microarray; Transfection; MTT; EdU Staining; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Low circFBXW7 levels were associated with a particular gene expression profile in T-ALL patients. |
| Description: |
In pediatric T-ALL, circFBXW7 is depleted/low in a patient subset and acts as a tumor-suppressive circRNA. Its knockdown increases leukemia cell viability and proliferation and is accompanied by activation of MYC targets and NOTCH signaling (including increased MYC and cleaved intracellular NOTCH1 protein levels), and it can increase Dexamethasone sensitivity. |
| Confidence score: |
0.6221 |