circRNA basic information
circBase ID: hsa_circ_0061265
Name: -
Synonym: circ_0061265
Host Gene: -
Genomic location(hg19): chr21:15456270-15456465:+
Genomic location(hg38): chr21:14083949-14084144:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal gastric tissues
Cell lines:

NCI-N87
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AURKA, AGO2
Associated microRNA: miR-885-3p
Biological function: promotes GC development; promotes proliferation and migration; inhibits apoptosis; promotes chemoresistance
Molecular mechanism: ceRNA (miRNA sponge): circ_0061265 competitively binds miR-885-3p to upregulate AURKA
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); chemoresistance (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Western Blot; IHC (Immunohistochemistry); RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0061265 is up-regulated in gastric cancer tissues/cells and promotes malignant phenotypes and cisplatin chemoresistance. It functions as a ceRNA by sponging miR-885-3p to increase AURKA expression.
Confidence score:

0.7932
Other information
Title:

circ_0061265 competitively binds to microRNA-885-3p to promote the development of gastric cancer by upregulating AURKA expression.

Journal: Cancer cell international
Published: 2022
PubMed ID: 36064409
Study type:

combined biological and clinical study
Data availability: GSE78092; TCGA
Code availability: -