circRNA basic information
circBase ID: hsa_circ_0058107
Name: hsa_circ_FN1
Synonym: -
Host Gene: FN1
Genomic location(hg19): chr2:216246934-216256537:-
Genomic location(hg38): chr2:215382211-215391814:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0044638
MONDO name: hypopharynx squamous cell carcinoma
Disease details: hypopharyngeal squamous cell carcinoma
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C4043
Disease ICD11 ID:
 680629191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HSCC tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-185-3p, miR-3137, miR-365b-5p, miR-4638-3p, miR-4673, miR-4722-5p, miR-4726-3p, miR-6751-5p, miR-6752-5p, miR-6803-5p, miR-6815-5p
Biological function: May inhibit apoptosis by sponging miR-185-3p in HSCC (speculative).
Molecular mechanism: Predicted miRNA sponge (ceRNA) mechanism within circRNA-miRNA-mRNA networks.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0058107 is up-regulated in HSCC tumor tissues and was validated by qRT-PCR. It is predicted to sponge multiple miRNAs (including miR-185-3p) in circRNA-miRNA-mRNA networks; the anti-apoptotic implication is discussed but not experimentally validated.
Confidence score:

0.585
Other information
Title:

Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.

Journal: Oncotarget
Published: 2017
PubMed ID: 28514762
Study type:

combined biological and clinical study
Data availability: -
Code availability: -