circRNA basic information
circBase ID: hsa_circ_0088036
Name: hsa_circ_SUSD1
Synonym: hsa_circRNA_104871
Host Gene: SUSD1
Genomic location(hg19): chr9:114840817-114842445:-
Genomic location(hg38): chr9:112078537-112080165:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: Amyotrophic lateral sclerosis
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

leukocyte samples; Peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential blood-based diagnostic biomarker (AUC > 0.950, sensitivity/specificity > 90%); negatively associated with age (blood collection and disease onset).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

AUC over 0.950 with sensitivity and specificity over 90% for ALS diagnosis; negatively associated with age.
Description:

hsa_circ_0088036 (SUSD1-derived) is up-regulated in ALS blood leukocytes/PBMCs and has strong diagnostic potential (AUC > 0.95, sensitivity/specificity > 90%). Its expression is negatively associated with patient age.
Confidence score:

0.5963
Other information
Title:

Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.

Journal: Molecular neurobiology
Published: 2019
PubMed ID: 31175544
Study type:

combined biological and clinical study
Data availability: -
Code availability: -