| Expression pattern: |
UP |
| Associated gene: |
KLF6, Ago2 |
| Associated microRNA: |
miR-769-5p |
| Biological function: |
Downregulation of circ_0097010 alleviates LPS-induced apoptosis and inflammation in hPDLCs and rescues LPS-imposed viability and proliferation defects. |
| Molecular mechanism: |
circ_0097010 functions as a ceRNA by sponging miR-769-5p, thereby regulating KLF6 expression; validated via luciferase reporter, Ago2-RIP, and RNA pull-down assays. |
| Biological pathway or process: |
apoptosis (inhibits); inflammation (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0097010 expression is increased in periodontitis gingival samples and is progressively upregulated with increasing severity; suggested potential diagnostic value of the circ_0097010/miR-769-5p/KLF6 cascade. |
| Description: |
circ_0097010 is upregulated in periodontitis gingival tissues and in LPS-stimulated hPDLCs. Silencing circ_0097010 reduces LPS-induced apoptosis and inflammatory/oxidative injury by acting as a sponge for miR-769-5p, thereby decreasing KLF6 expression (circ_0097010/miR-769-5p/KLF6 ceRNA axis). |
| Confidence score: |
0.779 |