| Expression pattern: |
DN |
| Associated gene: |
GNAS |
| Associated microRNA: |
miR-2278 |
| Biological function: |
Suppresses proliferation, migration and invasion; promotes apoptosis; inhibits xenograft tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-2278 to increase GNAS expression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
Potential biomarker for OSCC; associated with tumor size and lymph-node metastasis. |
| Description: |
circ_0004491 (circORC4; hsa_circ_0004491) is down-regulated in OSCC tissues and cell lines and functions as a tumor suppressor. It sponges miR-2278 to relieve repression of GNAS, thereby inhibiting proliferation/migration/invasion and promoting apoptosis, including reduced xenograft tumor growth. |
| Confidence score: |
0.8298 |