circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1(e2)
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004981
MONDO name: atrial fibrillation
Disease details: atrial fibrillation
Disease DO ID:
 0060224
Disease MeSH ID:
 D001281
Disease NCIt ID:
 C50466
Disease ICD11 ID:
 171698302
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

left atria junctions
Cell lines:

HUASMC; HASMC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: MYB
Associated microRNA: miR-298
Biological function: facilitates vascular smooth muscle cell viability/proliferation and inhibits apoptosis
Molecular mechanism: Acts as a ceRNA sponge for miR-298 to positively regulate MYB expression.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

potential indicator/target for diagnosis and treatment of smooth muscle-related disease (atrial fibrillation context)
Description:

In human vascular smooth muscle cell lines, circFAT1(e2) promotes cell viability/proliferation and inhibits apoptosis. Mechanistically, it sponges miR-298 to relieve repression of MYB, forming a circFAT1(e2)/miR-298/MYB axis linked by the authors to atrial fibrillation progression.
Confidence score:

0.5416
Other information
Title:

circFAT1(e2) Inhibits Cell Apoptosis and Facilitates Progression in Vascular Smooth Muscle Cells through miR-298/MYB Axis.

Journal: Computational and mathematical methods in medicine
Published: 2021
PubMed ID: 34938350
Study type:

combined biological and bioinformatics study
Data availability: GSE41177
Code availability: -