| Expression pattern: |
UP |
| Associated gene: |
ADAM9, E-cadherin, b-catenin, CCND1, MMP9, Survivin |
| Associated microRNA: |
miR-921 |
| Biological function: |
circNINL acts as an oncogene in breast cancer, promoting cell proliferation and migration/metastasis and restraining apoptosis. |
| Molecular mechanism: |
circNINL sponges miR-921 to regulate ADAM9 expression; ADAM9 interacts with E-cadherin and activates b-catenin signaling, increasing downstream oncogenes CCND1, MMP9 and Survivin. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Co-IP; Bioinformatics Analysis |
| Clinical significance: |
High circNINL expression is associated with malignant clinicopathologic features and poor prognosis, suggesting potential biomarker value for breast cancer. |
| Description: |
circNINL/hsa_circ_0092338 is up-regulated in breast cancer tissues and cell lines and is associated with malignant clinicopathologic features and poor prognosis. Functionally, circNINL promotes breast cancer cell proliferation and migration while inhibiting apoptosis. Mechanistically, it acts as a miR-921 sponge to regulate ADAM9, leading to activation of b-catenin signaling and increased expression of downstream oncogenes including CCND1, MMP9 and Survivin. |
| Confidence score: |
0.8058 |