| Expression pattern: |
UP |
| Associated gene: |
FOXK1 |
| Associated microRNA: |
miR-1275 |
| Biological function: |
circMAN2B2 acts as an oncogene in lung cancer; circMAN2B2 promotes lung cancer cell proliferation and invasion, while circMAN2B2 knockdown suppresses proliferation and invasion. |
| Molecular mechanism: |
circMAN2B2 sponges miR-1275 to repress miR-1275 and enhance FOXK1 expression, thereby promoting lung cancer cell proliferation and invasion. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
circMAN2B2 might be a potential therapeutic target for lung cancer intervention. |
| Description: |
circMAN2B2 is up-regulated in lung cancer tissues and cell lines. It promotes lung cancer cell proliferation and invasion by acting as a miR-1275 sponge, thereby increasing FOXK1 expression. The study suggests circMAN2B2 may serve as a potential therapeutic target for lung cancer. |
| Confidence score: |
0.6777 |