| Expression pattern: |
DN |
| Associated gene: |
S4 protein (X-linked), S8, S24, L7, L11, RPS4X, RPS8, RPS24, RPL7, RPL11 |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation and migration; suppresses tumorigenesis and metastasis |
| Molecular mechanism: |
binds ribosomal proteins and reduces ribosome production/biogenesis |
| Biological pathway or process: |
other pathway/process (inhibits); proliferation (inhibits); migration (inhibits); metastasis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; IF (Immunofluorescence) |
| Clinical significance: |
Low circTRPS1-2 expression predicts poor prognosis; patients with high circTRPS1-2 showed longer overall survival |
| Description: |
circTRPS1-2 (hsa_circ_0085362), derived from TRPS1, is down-regulated in ESCC tissues and cell lines. It suppresses ESCC cell proliferation, migration, tumor growth and metastasis, likely by binding multiple ribosomal proteins (RPS4X/RPS8/RPS24/RPL7/RPL11) and reducing ribosome biogenesis/production; higher expression is associated with better overall survival. |
| Confidence score: |
0.8671 |