| Expression pattern: |
UP |
| Associated gene: |
ARHGEF28 |
| Associated microRNA: |
miR-30c-2-3p |
| Biological function: |
Promotes breast cancer cell migration and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-30c-2-3p and may regulate ARHGEF28 expression. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay |
| Clinical significance: |
May serve as a novel biomarker for breast cancer. |
| Description: |
hsa_circ_0072995 is up-regulated in MDA-MB-231 breast cancer cells compared with MCF-7 cells. It promotes breast cancer cell migration and invasion, at least partly by acting as a sponge for miR-30c-2-3p, and it may also regulate its host gene ARHGEF28. The study suggests hsa_circ_0072995 may be a novel biomarker related to breast cancer metastasis. |
| Confidence score: |
0.7006 |