| Expression pattern: |
UP |
| Associated gene: |
Fas |
| Associated microRNA: |
hsa-miR-766-3p |
| Biological function: |
promotes intestinal epithelial apoptosis and inflammation; inhibits cell viability; aggravates intestinal injury and mucosal permeability dysfunction |
| Molecular mechanism: |
Acts as a cytoplasmic miRNA sponge (ceRNA) for miR-766-3p to enhance Fas expression and activate Fas-mediated extrinsic apoptosis signaling (FADD; caspase-8; caspase-3), leading to intestinal epithelial injury and inflammation during sepsis. |
| Biological pathway or process: |
apoptosis (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
The circFLNA/miR-766-3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis. |
| Description: |
circFLNA is up-regulated in intestinal epithelium during abdominal sepsis and in LPS-treated HIEC-6 cells. It localizes mainly in the cytoplasm and promotes intestinal epithelial apoptosis and inflammation by sponging miR-766-3p, thereby increasing Fas expression and activating the Fas-mediated extrinsic apoptosis pathway; circFLNA knockdown alleviates intestinal injury in the CLP mouse sepsis model. |
| Confidence score: |
0.8684 |