| Expression pattern: |
DN |
| Associated gene: |
NRIP1 |
| Associated microRNA: |
hsa-miR-7705, hsa-miR-6504-5p, hsa-miR-7974 |
| Biological function: |
tumor suppressor role; inhibits growth/proliferation and migration; induces G0/G1 arrest |
| Molecular mechanism: |
miRNA sponge effect via binding to hsa-miR-7705 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); cell cycle (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; RT-ddPCR |
| Clinical significance: |
plasma hsa_circ_0061276 has diagnostic value for distinguishing healthy people from early gastric cancer and advanced gastric cancer; potential biomarker |
| Description: |
In gastric cancer, hsa_circ_0061276 is decreased in plasma and gastric cancer cell lines/tissues and shows diagnostic potential by RT-ddPCR with ROC performance for early and advanced disease. Functionally, it acts as a tumor suppressor by inhibiting proliferation and migration and inducing G0/G1 arrest. Mechanistically, it functions mainly in the cytoplasm as a miRNA sponge, with validated binding to hsa-miR-7705. |
| Confidence score: |
0.7941 |