circRNA basic information
circBase ID: -
Name: mmu_circ_CDR1
Synonym: CDR1as / ciRS-7
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: ischemic stroke / IS
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

peri-infarct cortex / cerebral peri-infarct region / cortical tissue
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: Ago2, alpha-synuclein
Associated microRNA: miR-7, miR-671
Biological function: Neuroprotective after stroke; suppresses post-ischemic alpha-Syn induction; promotes motor function recovery; decreases infarct size; curtails apoptosis, autophagy, mitochondrial fragmentation, and inflammation.
Molecular mechanism: Controls miR-7 availability by binding to Ago2/miR-7 complex, thereby protecting miR-7 and preventing derepression of alpha-Syn after ischemia.
Biological pathway or process:

apoptosis (inhibits); autophagy (inhibits); mitochondrial function (other); inflammation (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; RIP (RNA Immunoprecipitation); Transfection; Western Blot; IHC (Immunohistochemistry); IF (Immunofluorescence); In Vivo Animal Model
Clinical significance:

-
Description:

In mouse transient MCAO, CDR1as is down-regulated in peri-infarct cortex. Reconstitution/overexpression of CDR1as preserves miR-7 availability (via Ago2-associated binding), suppresses alpha-synuclein induction, and reduces secondary ischemic brain injury with improved motor recovery, partly by limiting apoptosis, autophagy, mitochondrial fragmentation, and inflammation.
Confidence score:

0.6916
Other information
Title:

CDR1as regulates alpha-synuclein-mediated ischemic brain damage by controlling miR-7 availability.

Journal: Molecular therapy. Nucleic acids
Published: 2023
PubMed ID: 36618263
Study type:

biological research
Data availability: https://doi.org/10.1016/j.omtn.2022.11.022
Code availability: -