| Expression pattern: |
DN |
| Associated gene: |
ARRB1, Ki-67, P-gp, GST-pi, MDM2, MGMT |
| Associated microRNA: |
miR-665 |
| Biological function: |
circ_0017636 acts as a tumor suppressor, inhibits proliferation, migration and invasion, restores TMZ sensitivity, suppresses xenograft tumor growth, and propagates chemosensitivity via exosomal transfer. |
| Molecular mechanism: |
circ_0017636 functions as a ceRNA that sponges miR-665 to de-repress ARRB1; exosome-mediated delivery transfers circ_0017636 to recipient GBM cells and restores chemosensitivity. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); drug resistance (inhibits); chemoresistance (inhibits); ceRNA regulation (other); p53 signaling (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0017636 is associated with TMZ resistance and prognosis, has diagnostic potential for distinguishing GBM from normal tissues, and may serve as a prognostic biomarker and therapeutic target. |
| Description: |
circ_0017636 is a downregulated tumor-suppressive circRNA in GBM and TMZ-resistant GBM. It reverses TMZ resistance and suppresses malignant phenotypes by sponging miR-665 to restore ARRB1 expression, and exosome-mediated delivery of circ_0017636 propagates chemosensitivity and inhibits xenograft tumor growth. Low circ_0017636 expression is associated with poorer overall survival, while its expression shows diagnostic potential for GBM. |
| Confidence score: |
0.863 |