| Expression pattern: |
UP |
| Associated gene: |
SNIP1, Ago2 |
| Associated microRNA: |
miR-335 |
| Biological function: |
promotes osteosarcoma malignancy, proliferation, migration and invasion; silencing inhibits tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponging miR-335 to upregulate SNIP1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Sanger Sequencing; RNase R Treatment; FISH / smFISH; divergent primers PCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circUSP48 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion by sponging miR-335 and thereby upregulating SNIP1; circUSP48 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8635 |