| Expression pattern: |
UP |
| Associated gene: |
HOXA13, Ago2 |
| Associated microRNA: |
miR-203a-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, EMT, and tumor growth in vivo; circ_0070934 knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
circ_0070934 functions as a molecular sponge of miR-203a-3p and modulates HOXA13 expression through the miR-203a-3p/HOXA13 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0070934 expression is associated with more advanced TNM stage, more lymph node and distal node metastasis, poorer tumor differentiation, and poor overall survival; circ_0070934 is a candidate prognostic biomarker. |
| Description: |
circ_0070934 is up-regulated in colorectal cancer tissues and cells and high expression is associated with aggressive clinicopathologic features and poor prognosis. Functionally, circ_0070934 promotes CRC cell proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a sponge for miR-203a-3p to regulate the downstream HOXA13 axis. |
| Confidence score: |
0.8557 |