| Expression pattern: |
UP |
| Associated gene: |
IGF1, Ago2 |
| Associated microRNA: |
miR-15a-5p |
| Biological function: |
promotes sorafenib resistance and suppresses sorafenib toxicity in HCC cells |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-15a-5p, relieving repression of IGF1 and increasing IGF1 levels to promote sorafenib resistance. |
| Biological pathway or process: |
chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; ELISA |
| Clinical significance: |
Higher hsa_circ_0006988 expression in SOR-R patients is associated with reduced 5-year overall survival. |
| Description: |
In sorafenib-resistant HCC, hsa_circ_0006988 is up-regulated and promotes sorafenib resistance. Mechanistically, it sponges miR-15a-5p to relieve repression on IGF1, increasing IGF1 levels and reducing sorafenib toxicity. |
| Confidence score: |
0.7842 |