circRNA basic information
circBase ID: hsa_circ_0069313
Name: hsa_circ_PACRGL
Synonym: circPACRGL
Host Gene: PACRGL
Genomic location(hg19): chr4:20702035-20729980:+
Genomic location(hg38): chr4:20700412-20728357:+
Subcellular localization: exosome; extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a circulating serum and serum exosomal biomarker candidate for discriminating NSCLC from benign lung tumor and is associated with aggressive clinicopathological features including higher stage, lymph node metastasis and distant metastasis.
Molecular mechanism: No disease mechanism was experimentally defined in NSCLC; the study focused on serum and serum exosomal expression and diagnostic/clinicopathological associations.
Biological pathway or process:

metastasis (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum and serum exosomal hsa_circ_0069313 can discriminate NSCLC from benign lung tumor; higher serum exosomal levels are linked to stage III-IV, lymph node metastasis and distant metastasis.
Description:

hsa_circ_0069313 was validated by qRT-PCR as up-regulated in serum and serum exosomes of NSCLC patients. Its serum and serum exosomal levels showed diagnostic potential for distinguishing NSCLC from benign lung tumor, and higher serum exosomal levels were associated with more aggressive NSCLC features including advanced stage and metastasis.
Confidence score:

0.5047
Other information
Title:

Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.

Journal: Clinical biochemistry
Published: 2022
PubMed ID: 35077682
Study type:

combined clinical and bioinformatics study
Data availability: Supplementary data to this article can be found online at https://doi. org/10.1016/j.clinbiochem.2022.01.005.
Code availability: -