| Expression pattern: |
DN |
| Associated gene: |
KLF4 |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for colorectal cancer; associated with invasion and distal metastasis |
| Molecular mechanism: |
Predicted to act as a KLF4 competing endogenous RNA (ceRNA); expression positively correlated with KLF4 |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
May be served as a potential biomarker for the diagnosis of CRC; AUC 0.818 (training) and 0.942 (confirm) in ROC analysis; expression associated with age, differentiation, invasion, distal metastasis, TNM stage, and CEA |
| Description: |
hsa_circ_0142527 is significantly down-regulated in colorectal cancer tissues versus adjacent tissues and is positively correlated with KLF4, being predicted as a KLF4-related ceRNA. It shows diagnostic potential (high AUC in ROC analysis) and its expression is associated with multiple clinicopathological features including invasion, distal metastasis, and TNM stage. |
| Confidence score: |
0.6556 |