circRNA basic information
circBase ID: hsa_circ_0142527
Name: hsa_circ_PREX2
Synonym: -
Host Gene: PREX2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
5672, 9256
Disease MeSH ID:
-
Disease NCIt ID:
C4978
Disease ICD11 ID:
-
Disease OMIM ID:
114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues / paracancerous tissues

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: KLF4
Associated microRNA: -
Biological function: Potential diagnostic biomarker for colorectal cancer; associated with invasion and distal metastasis
Molecular mechanism: Predicted to act as a KLF4 competing endogenous RNA (ceRNA); expression positively correlated with KLF4
Biological pathway or process:

ceRNA regulation (other)

Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis

Clinical significance:

May be served as a potential biomarker for the diagnosis of CRC; AUC 0.818 (training) and 0.942 (confirm) in ROC analysis; expression associated with age, differentiation, invasion, distal metastasis, TNM stage, and CEA

Description:

hsa_circ_0142527 is significantly down-regulated in colorectal cancer tissues versus adjacent tissues and is positively correlated with KLF4, being predicted as a KLF4-related ceRNA. It shows diagnostic potential (high AUC in ROC analysis) and its expression is associated with multiple clinicopathological features including invasion, distal metastasis, and TNM stage.

Confidence score:

0.6556

Other information
Title:

Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing.

Journal: Journal of clinical laboratory analysis
Published: 2019
PubMed ID: 31169949
Study type:

combined biological and clinical study

Data availability: GSE121842
Code availability: -