| Expression pattern: |
DN |
| Associated gene: |
SOX9, Ago2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes proliferation and suppresses apoptosis and ECM degradation in IL-1beta-induced chondrocytes |
| Molecular mechanism: |
ceRNA mechanism: circ_0008365 sponges miR-338-3p to regulate SOX9 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
exosomal circ_0008365 had a diagnostic performance in OA with an AUC of 92.95% |
| Description: |
circ_0008365 is down-regulated in OA cartilage and in IL-1beta-treated CHON-001 cells. It alleviates IL-1beta-induced chondrocyte injury by sponging miR-338-3p and restoring SOX9, thereby promoting proliferation and inhibiting apoptosis and extracellular matrix degradation. Serum exosomal circ_0008365 shows diagnostic potential for OA (high AUC). |
| Confidence score: |
0.8562 |