| Expression pattern: |
UP |
| Associated gene: |
FGFR3, STAT3 |
| Associated microRNA: |
miR-181a-5p |
| Biological function: |
promotes proliferation and migration; inhibits apoptosis; promotes tumour growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-181a-5p to de-repress FGFR3, activating STAT3 signaling |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes); JAK/STAT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may serve as a potential biomarker; positively correlated with T-stage and N-stage |
| Description: |
hsa_circ_0068871 is up-regulated in bladder cancer and promotes proliferation, migration, and xenograft growth while reducing apoptosis. It functions as a ceRNA sponge for miR-181a-5p, relieving repression of FGFR3 and activating STAT3 signaling, and may serve as a biomarker. |
| Confidence score: |
0.8571 |