| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential blood biomarker associated with PD; included among high-confidence circRNAs not driven by cell composition or medication. |
| Molecular mechanism: |
Predicted miRNA targeting (in-silico) with circRNA-miRNA correlations; downstream pathway enrichment via miRNAs. |
| Biological pathway or process: |
Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Identified as a high-confidence blood circRNA associated with PD. |
| Description: |
circETFA is decreased in blood of sporadic PD participants versus controls and is one of the five high-confidence circRNAs followed up by the study. Its broader biological context was explored via predicted miRNA targets and pathway enrichment analyses. |
| Confidence score: |
0.348 |