| Expression pattern: |
DN |
| Associated gene: |
TIMP2 |
| Associated microRNA: |
miR-122-5p |
| Biological function: |
Suppresses proliferation, migration and invasion and promotes apoptosis in ccRCC cells; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-122-5p to promote TIMP2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target and early diagnostic target for ccRCC. |
| Description: |
circ_DENND1B is down-regulated in ccRCC tissues/cells. Its overexpression suppresses proliferation, migration, invasion and EMT while promoting apoptosis, and inhibits xenograft tumor growth by sponging miR-122-5p to upregulate TIMP2. |
| Confidence score: |
0.7955 |