| Expression pattern: |
UP |
| Associated gene: |
GOT2 |
| Associated microRNA: |
miR-342-3p |
| Biological function: |
promotes proliferation, migration, invasion, and angiogenesis; inhibits apoptosis in NSCLC cells |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-342-3p to up-regulate GOT2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circ_0006220 was upregulated in serum samples of NSCLC patients and high circ_0006220 expression was correlated with advanced TNM stages, distant metastasis, and shorter survival time. |
| Description: |
Circ_0006220 is up-regulated in NSCLC tissues, cell lines, and patient serum, and higher levels associate with advanced disease and worse survival. Functionally, it promotes NSCLC malignant phenotypes by acting as a ceRNA that sponges miR-342-3p and thereby increases GOT2 expression, enhancing proliferation, migration/invasion, and angiogenesis while suppressing apoptosis. |
| Confidence score: |
0.8498 |