| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
participates in intercellular communication (exported and efficiently taken up; strongest uptake among tested circLSD1 RNAs) |
| Molecular mechanism: |
released extracellularly (EVs/RNP-associated) and transferred to recipient cells; can be detected in patient serum |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; FISH / smFISH; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Bioinformatics Analysis |
| Clinical significance: |
detected in serum of T-PLL patients but not in healthy donors |
| Description: |
hsa_circ_0112434 (circ 2a_2) is a KDM1A-derived circRNA that is mainly cytoplasmic, can be released extracellularly (EV/RNP-associated), and is efficiently taken up by recipient lung cells. It is also detectable in serum from T-PLL patients but not healthy donors, supporting its presence as a circulating extracellular RNA. |
| Confidence score: |
0.695 |