| Expression pattern: |
DN |
| Associated gene: |
PI3K, Akt, p-Akt, p53, Bcl-2, cyclin D1 |
| Associated microRNA: |
miR-630 |
| Biological function: |
Inhibits proliferation, migration, invasion and EMT; promotes cell cycle arrest (G0/G1) and apoptosis; suppresses tumor growth and metastasis in vivo. |
| Molecular mechanism: |
Inactivates PI3K/Akt signaling; negatively correlates with PI3K; proposed (from prior report) targeting miR-630. |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); apoptosis (promotes); cell cycle (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
Low hsa_circRNA_100269 is associated with advanced grade and metastasis; low expression shows reduced overall survival; circRNA_100269 expression is an independent risk factor for prognosis. |
| Description: |
hsa_circRNA_100269 is down-regulated in gastric cancer and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion and EMT while promoting G0/G1 arrest and apoptosis, at least partly by inactivating the PI3K/Akt signaling axis, and it suppresses xenograft growth/metastasis in vivo. |
| Confidence score: |
0.622 |