| Expression pattern: |
DN |
| Associated gene: |
HuR, LACTB |
| Associated microRNA: |
miR-373-5p |
| Biological function: |
inhibits CRC cell growth, migration, invasion and metastasis; may inhibit angiogenesis |
| Molecular mechanism: |
binds HuR to promote LACTB mRNA stability; acts as a ceRNA sponge for miR-373-5p to increase LACTB expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); angiogenesis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; ISH (In Situ Hybridization); RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circ0104103 expression was correlated with tumor invasion depth and TNM stage; may be a novel biomarker and therapeutic target in CRC |
| Description: |
circ0104103 is down-regulated in colorectal cancer and functions as a tumor suppressor by inhibiting proliferation, migration/invasion, and metastasis. It increases LACTB expression through dual mechanisms: binding HuR to enhance LACTB mRNA stability and sponging miR-373-5p to relieve repression of LACTB. |
| Confidence score: |
0.8817 |