| Expression pattern: |
UP |
| Associated gene: |
AR |
| Associated microRNA: |
- |
| Biological function: |
circ-SMARCA5 acts as an oncogenic circRNA in prostate cancer, promoting cell proliferation and cell cycle progression while inhibiting apoptosis. |
| Molecular mechanism: |
circ-SMARCA5 is androgen-induced; its knockdown represses cell cycle progression, inhibits proliferation, and promotes apoptosis in prostate cancer cells. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay |
| Clinical significance: |
up-regulating circ-SMARCA5 can be used as a diagnostic biomarker of PCa; it may also be a potential therapeutic and prognostic target for prostate cancer. |
| Description: |
circ-SMARCA5 is a human SMARCA5-derived circRNA up-regulated in prostate cancer tissues and cell lines. It is androgen-inducible and functions as an oncogenic circRNA by promoting proliferation and cell cycle progression while inhibiting apoptosis, suggesting potential diagnostic and therapeutic relevance in PCa. |
| Confidence score: |
0.5751 |