| Expression pattern: |
UP |
| Associated gene: |
S1PR5, STAT3, TBR1, BMPR1B |
| Associated microRNA: |
hsa-miR-639, hsa-miR-4449 |
| Biological function: |
Potential diagnostic biomarker for IMN; may promote IMN progression and is positively correlated with proteinuria. |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network (binding miRNAs to relieve suppression of target mRNAs). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Urinary exosomal hsa_circ_0001250 showed diagnostic potential for IMN (AUC=0.8034 vs HC; AUC=0.7872 vs INS) and higher expression correlated with higher proteinuria. |
| Description: |
Urinary exosomal hsa_circ_0001250 is significantly up-regulated in IMN and correlates with proteinuria. It shows diagnostic value for distinguishing IMN from healthy controls and INS, and is predicted to act via a circRNA-miRNA-mRNA (ceRNA) network involving hsa-miR-639 and hsa-miR-4449 with downstream targets such as S1PR5 and STAT3. |
| Confidence score: |
0.6841 |