circRNA basic information
circBase ID: hsa_circ_0000711
Name: hsa_circ_NFATC3
Synonym: -
Host Gene: NFATC3
Genomic location(hg19): chr16:68155889-68160513:+
Genomic location(hg38): chr16:68121986-68126610:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; paired adjacent nontumorous tissues
Cell lines:

HCT116; COLO205; HT29; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May play a crucial role in CRC carcinogenesis; low expression is associated with poor overall survival and has diagnostic value.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

AUC was 0.81 (sensitivity 0.91, specificity 0.58) for CRC diagnosis; low expression is an independent unfavorable prognostic factor for OS.
Description:

hsa_circ_0000711 is significantly down-regulated in CRC tissues and CRC cell lines. Lower hsa_circ_0000711 expression is associated with poorer overall survival and may serve as an independent prognostic factor, and it shows diagnostic potential (AUC 0.81) for CRC.
Confidence score:

0.6355
Other information
Title:

The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer.

Journal: Cancer management and research
Published: 2018
PubMed ID: 30147374
Study type:

combined biological and clinical study
Data availability: -
Code availability: -