| Expression pattern: |
UP |
| Associated gene: |
KLF6 |
| Associated microRNA: |
- |
| Biological function: |
Promotes ovarian cancer cell proliferation, migration, invasion, metastasis and tumorigenesis. |
| Molecular mechanism: |
circ-SMAD7 promotes ovarian cancer progression by suppressing KLF6 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-SMAD7 may be a novel therapeutic strategy and candidate target in ovarian cancer. |
| Description: |
circ-SMAD7 is up-regulated in ovarian cancer tissues and cell lines. Functional knockdown experiments indicate that it promotes ovarian cancer cell proliferation, migration and invasion, potentially through suppressing KLF6 expression. The study suggests circ-SMAD7 may serve as a therapeutic candidate target in ovarian cancer. |
| Confidence score: |
0.5751 |