circRNA basic information
circBase ID: hsa_circ_0004662
Name: hsa_circ_SOD2
Synonym: circSOD2
Host Gene: SOD2
Genomic location(hg19): chr6:160103505-160109274:-
Genomic location(hg38): chr6:159682473-159688242:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013209
MONDO name: metabolic dysfunction-associated steatotic liver disease
Disease details: metabolic-associated fatty liver disease / MAFLD
Disease DO ID:
 0080208
Disease MeSH ID:
 D065626
Disease NCIt ID:
 C84444
Disease ICD11 ID:
 1912806631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissues; serum; bone marrow
Cell lines:

HEK-293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: AGO2
Associated microRNA: miR-29b
Biological function: inhibits osteogenic differentiation of BMSCs and in vivo bone formation
Molecular mechanism: Acts as a miRNA sponge for miR-29b (ceRNA mechanism), supported by luciferase reporter assay and cytoplasmic co-localization by FISH.
Biological pathway or process:

osteogenesis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
S
M
Validation methods:

RT-qPCR; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; In Vivo Animal Model; H&E Staining; Oil Red O Staining; RNA-seq; Microarray
Clinical significance:

circSOD2 may represent a promising and noninvasive biomarker for MAFLD
Description:

circSOD2 (hsa_circ_0004662) is up-regulated in MAFLD liver/primary hepatocytes and can be delivered from hepatocytes to BMSCs. It suppresses osteogenic differentiation and in vivo bone formation by sponging miR-29b, supported by RIP/RAP, luciferase reporter assays, and cytoplasmic co-localization by FISH.
Confidence score:

0.7385
Other information
Title:

Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease.

Journal: World journal of gastroenterology
Published: 2025
PubMed ID: 40061587
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon reasonable request at loujianying@zju.edu.cn.
Code availability: -