circRNA basic information
circBase ID: hsa_circ_0005505
Name: hsa_circ_IRAK3
Synonym: -
Host Gene: IRAK3
Genomic location(hg19): chr12:66597490-66622150:+
Genomic location(hg38): chr12:66203710-66228370:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013792
MONDO name: intracerebral hemorrhage
Disease details: intracerebral hemorrhage / ICH
Disease DO ID:
 -
Disease MeSH ID:
 D002543
Disease NCIt ID:
 -
Disease ICD11 ID:
 873092535
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for ICH.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Upregulated in ICH and helps identify ICH when combined with circERBB2 and circCHST12 (AUC 0.946 vs controls; AUC 0.799 vs IS).
Description:

hsa_circ_0005505 is up-regulated in peripheral blood from ICH patients and is part of a circRNA signature that improves diagnostic discrimination of ICH from healthy controls and from IS when combined with circERBB2 and circCHST12.
Confidence score:

0.5047
Other information
Title:

Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.

Journal: Frontiers in neuroscience
Published: 2022
PubMed ID: 36523430
Study type:

combined biological and clinical study
Data availability: GSA-Human: HRA001807
Code availability: -