circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: circERBB2
Host Gene: ERBB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013792
MONDO name: intracerebral hemorrhage
Disease details: intracerebral hemorrhage / ICH
Disease DO ID:
 -
Disease MeSH ID:
 D002543
Disease NCIt ID:
 -
Disease ICD11 ID:
 873092535
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for ICH; may be involved in the pathogenesis of ICH.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic biomarker for distinguishing ICH from healthy controls and from IS; ROC AUC 0.883 for circERBB2 alone and 0.917 when combined with circCHST12.
Description:

circERBB2 is a novel ERBB2-derived circRNA that is down-regulated in peripheral blood from ICH patients. It was validated as a bona fide circRNA and shows diagnostic value for distinguishing ICH from healthy controls (and also differs between ICH and IS), especially when combined with circCHST12 and clinical risk factors.
Confidence score:

0.6841
Other information
Title:

Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.

Journal: Frontiers in neuroscience
Published: 2022
PubMed ID: 36523430
Study type:

combined biological and clinical study
Data availability: GSA-Human: HRA001807
Code availability: -