| Expression pattern: |
UP |
| Associated gene: |
FOXP3, IGF2BP2, Ago2 |
| Associated microRNA: |
miR-449b-5p |
| Biological function: |
promotes ESCC cell proliferation, migration, invasion and metastasis |
| Molecular mechanism: |
circRUNX1 functions as a ceRNA to sponge miR-449b-5p and increase FOXP3 expression; IGF2BP2 binds circRUNX1 and prevents its degradation (m6A-dependent). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA-seq; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circRUNX1 was associated with TNM stage and differentiation grade; ROC AUC 0.894 indicates it could distinguish cancer and paracancerous tissues in ESCC patients; potential diagnostic marker and therapeutic target |
| Description: |
circRUNX1 is up-regulated in ESCC and promotes proliferation and metastasis. It acts as a ceRNA by sponging miR-449b-5p to increase FOXP3 expression, and its stability is enhanced by IGF2BP2 binding in an m6A-dependent manner. circRUNX1 shows diagnostic potential (ROC AUC 0.894) and correlates with advanced TNM stage and poor differentiation. |
| Confidence score: |
0.8837 |