circRNA basic information
circBase ID: hsa_circ_0082843
Name: hsa_circ_EZH2
Synonym: circEZH2E2‐E8
Host Gene: EZH2
Genomic location(hg19): chr7:148523560-148544397:-
Genomic location(hg38): chr7:148826468-148847305:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate cancer tissue samples; BPH tissue samples
Cell lines:

DU145; PC-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circEZH2E2-E8 (hsa_circ_0082843) is an EZH2-derived circRNA detected in prostate cancer cell lines and is overexpressed in PCa cells and tissue samples. The study did not further characterize its mechanism, functional phenotypes, or clinical prognostic value.
Confidence score:

0.5129
Other information
Title:

circEZH2E2 /E3 is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.

Journal: Cancer science
Published: 2023
PubMed ID: 36519785
Study type:

combined biological and clinical study
Data availability: -
Code availability: -