| Expression pattern: |
UP |
| Associated gene: |
SLC7A11 |
| Associated microRNA: |
miR-876-5p |
| Biological function: |
Acts as an oncogene in OSCC; promotes autophagy, cell cycle progression, proliferation, migration, invasion, metastasis and tumor growth; represses apoptosis. |
| Molecular mechanism: |
circCDR1as functions through a ceRNA mechanism by sponging miR-876-5p, thereby elevating SLC7A11 expression and regulating autophagy-related malignant behaviors in OSCC. |
| Biological pathway or process: |
autophagy (promotes); cell cycle (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Western Blot; Cell Cycle Assay; Annexin V/PI Flow Cytometry; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
High circCDR1as expression was associated with advanced TNM stage and lymphatic metastasis in OSCC patients. |
| Description: |
circCDR1as is up-regulated in OSCC tissues and cell lines and functions as an oncogenic circRNA. It promotes autophagy, cell cycle progression, proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, mainly through the circCDR1as/miR-876-5p/SLC7A11 ceRNA axis. |
| Confidence score: |
0.7554 |