| Expression pattern: |
UP |
| Associated gene: |
OAS1 |
| Associated microRNA: |
hsa-miR-502-5p |
| Biological function: |
promotes viability, proliferation, migration, invasion and EMT in LUAD cells |
| Molecular mechanism: |
ceRNA/sponging suggested via hsa_circ_0079557-hsa-miR-502-5p-OAS1 axis (network-based; not experimentally validated in LUAD) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
hsa_circ_0079557 is significantly higher in blood samples from LUAD patients than benign lesions (potential biomarker implication). |
| Description: |
hsa_circ_0079557 is up-regulated in LUAD (cell lines and patient blood). Its knockdown suppresses LUAD cell proliferation/viability and reduces migration and invasion, partly consistent with inhibition of EMT marker changes. The circRNA is placed in a predicted ceRNA network involving hsa-miR-502-5p and OAS1. |
| Confidence score: |
0.5802 |