| Expression pattern: |
UP |
| Associated gene: |
RAB1A |
| Associated microRNA: |
miR-19a-3p |
| Biological function: |
promotes HCC cell proliferation/viability, migration, invasion and resistance to apoptosis; promotes xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ_002136 sponges miR-19a-3p to increase RAB1A expression, promoting HCC progression; exosome-mediated transfer of circ_002136 between HCC cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; TUNEL; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_002136 level is associated with advanced tumor features and predicts worse survival in HCC patients |
| Description: |
circ_002136 is up-regulated in HCC tissues/cells and enriched in HCC-derived exosomes, enabling intercellular transfer. Functionally, circ_002136 promotes HCC proliferation, migration/invasion and anti-apoptosis, and its knockdown suppresses xenograft tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-19a-3p to increase RAB1A, and high circ_002136 is associated with poor patient survival. |
| Confidence score: |
0.7548 |