| Expression pattern: |
UP |
| Associated gene: |
IL-6 |
| Associated microRNA: |
miR-149-3p |
| Biological function: |
Enhances tumorigenesis; stimulates NSCLC cell proliferation, migration and invasion in vitro; promotes tumor growth in vivo. |
| Molecular mechanism: |
circFOXK2 acts as a miR-149-3p sponge to modulate IL-6 expression, enhancing NSCLC tumorigenesis through the miR-149-3p/IL-6 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circFOXK2 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC proliferation, migration, invasion, and in vivo tumor growth by sponging miR-149-3p and increasing IL-6 expression through the circFOXK2/miR-149-3p/IL-6 axis. |
| Confidence score: |
0.6835 |