circRNA basic information
circBase ID: hsa_circ_0004018
Name: hsa_circ_SMYD4
Synonym: -
Host Gene: SMYD4
Genomic location(hg19): chr17:1703150-1704318:-
Genomic location(hg38): chr17:1799856-1801024:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent nontumor tissues (NT)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: High tissue expression is associated with favorable progression-free survival (tumor-suppressor-like prognostic association).
Molecular mechanism: Not directly identified in this study.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

High expression of hsa_circ_0004018 is an inversely independent risk factor for progression-free survival in HBV-HCC (HR 0.435, p=0.005).
Description:

hsa_circ_0004018 is down-regulated in HBV-HCC tumor tissues versus adjacent nontumor tissues. Higher tissue expression is independently associated with longer progression-free survival, supporting its value as a favorable prognostic biomarker in HBV-HCC; this study did not experimentally define its molecular mechanism.
Confidence score:

0.5727
Other information
Title:

Tissue Circular RNA_0004018 and 0003570 as Novel Prognostic Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma.

Journal: Genes
Published: 2023
PubMed ID: 37895312
Study type:

clinical study
Data availability: The data used to support the findings of this study are available from the corresponding authors upon request.
Code availability: -