circRNA basic information
circBase ID: hsa_circ_0007990
Name: hsa_circ_PGAP3
Synonym: hsa_circRNA_0007990 / hsa_circPGAP3_003
Host Gene: PGAP3
Genomic location(hg19): chr17:37840849-37842272:-
Genomic location(hg38): chr17:39684596-39686019:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005291
MONDO name: brain aneurysm
Disease details: intracranial aneurysms / IA
Disease DO ID:
 10941
Disease MeSH ID:
 D002532
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; peripheral whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Ago2, DGCR8, EIF4A3, PTB, period circadian regulator 1, HIF1A, ESR1, FOXO1, IGF1, CREBBP, SMAD2, KLF4, ATM, PDGFRB, PTK2
Associated microRNA: miR-4717-5p, miR-1275, miR-150-3p, miR-18a-5p, miR-18b-5p
Biological function: Potential inflammatory blood biomarker associated with aneurysm wall enhancement in UIA.
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA) and predicted binding to RNA-binding proteins; potential protein-coding capacity (PER1 superfamily).
Biological pathway or process:

inflammation (other); ceRNA regulation (other); Hippo/YAP (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Cohort Study; Clinical Sample Validation
Clinical significance:

Blood hsa_circ_0007990 is associated with aneurysm wall enhancement on HR-VWI in UIA and may serve as an inflammatory biomarker for assessing UIA patients.
Description:

hsa_circ_0007990 is up-regulated in peripheral blood of UIA patients, showing a graded increase from healthy controls to UIA without AWE to UIA with AWE. The study proposes it as a blood inflammatory biomarker and builds a predicted circRNA-miRNA-mRNA (ceRNA) network with five miRNAs and inflammatory-response hub genes; RBP binding and protein-coding potential (PER1 superfamily) were also predicted.
Confidence score:

0.5963
Other information
Title:

Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 36466848
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061592/full#supplementary-material
Code availability: -