circRNA basic information
circBase ID: hsa_circ_0101338
Name: -
Synonym: hsa_circ0101338 / circ_0101338
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

human colon tissue; colorectal adenoma tissues; CRC tissues; adjacent normal tissues
Cell lines:

HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-661, hsa-miR-4755-3p, hsa-miR-1273g-3p
Biological function: acts as a miRNA sponge; early predictive biomarker for CRC malignant transformation
Molecular mechanism: ceRNA (miRNA sponge) mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA Pull-Down; Transfection
Clinical significance:

ROC analysis showed diagnostic value in discriminating CRA from normal and CRC from CRA; proposed as early predictive biomarker of CRC
Description:

hsa_circ0101338 is upregulated from normal to CRA and further to CRC in clinical tissues and shows strong diagnostic performance by ROC. Mechanistically, it functions as a miRNA sponge in CRC cells, binding miR-661, miR-4755-3p and miR-1273g-3p as supported by RNA pull-down after prediction.
Confidence score:

0.6616
Other information
Title:

The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers.

Journal: Aging
Published: 2022
PubMed ID: 36446351
Study type:

combined biological and clinical study
Data availability: -
Code availability: -