| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential circulating diagnostic biomarker for breast cancer; low plasma expression correlates with poor prognosis and is associated with axillary lymph node metastasis and TNM stage. |
| Molecular mechanism: |
Predicted miRNA sponging with downstream pathway involvement based on bioinformatics. |
| Biological pathway or process: |
PI3K/AKT (other); VEGF/VEGFR (other); other pathway/process (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circulating biomarker for BC diagnosis; low plasma expression correlates with poor prognosis; predictive ability for ALN metastasis (alone and combined with ultrasound). |
| Description: |
hsa_circ_0000091 is down-regulated in breast cancer patient plasma and is part of a 3-circRNA diagnostic model with high AUC. Lower plasma hsa_circ_0000091 is associated with metastasis-related features and poorer patient prognosis; mechanistically it is predicted (not experimentally validated) to act via miRNA sponging and cancer-related pathways. |
| Confidence score: |
0.5534 |